what to look for in a 2 hander

In the fights where i am not tanking - i would like to have a good 2-hander to pull out.. Besides farming Kara - whould Hammer of destiny be a good choice?.. or the BOE axe or mace or sword? or should I farm honor for it?

Get the Hammer of the Naaru from HKM, works perfectly well if you just want a big smashie thing for those times when your not tanking.
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It's not your job to die for your group, its to make the other guy die for his group.(Patton)paraphrased
http://www.wowarmory.com/character-sheet.xml?r=Burning+Legion&n=Morrioghan

...If you're alliance and have to revert to SoC something slow.
If you're horde and don't really care about speed just go for the highest "DPS" you can get your hands on.
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I got tricked from Blizz........ I thought that going Armorsmith would be beneficial for tanking. I was wrong. I decided to go Hammersmith and pull out Deep Thunder when I need to smack things, like those damn magic immune mana fishies in Kara right past Curator.
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Rogues hate me

if you are a Blood Elf, the 150 badge axe is by far the best choice.

If you are alliance and don't have seal of command, honestly you would be doing more for the raid by healing instead.

I only tend to use my 2hander to dps if I actually spec ret occasionally, but I did get one made for tanking...
The Hammer of Righteous Might (http://www.wowhead.com/?item=32854)
I don't get to 2htank very often, but it is pretty much the only way I can tank normal instances without taking half my gear off (issues with bag space). It has a very nice speed for a 2hander, which means I can usually get full benefit of reckoning with it.
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Telleryn - Bloodelf Tankadin - Mark of the Beast - Terenas-EU